Genetic Polymorphisms and Cisplatin- Related Nephrotoxicity
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چکیده
منابع مشابه
Genetic Polymorphisms and Cisplatin- Related Nephrotoxicity
Cisplatin is one of the most widely applied antineoplastic agents used to treat different types of solid tumours. However, its use is limited by serious sideeffects including nephrotoxicity. Cisplatin accumulates in proximal tubule and forms nephrotoxins that causes proximal cell injury and thereby leads to nephrotoxicity. Cisplatin enters these proximal cells by organic transporter molecules (...
متن کاملCisplatin nephrotoxicity.
Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly and predictably after initial and repeated exposure. The kidney accumulates cisplatin to a higher degree than other organs perhaps via mediated transport. Functionally, reduced renal perfusion and a concentrating defect characterize its nep...
متن کاملCisplatin therapy and the problem of gender-related nephrotoxicity
*Corresponding author: Prof. Hamid Nasri, Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail: [email protected] It is established that cisplatin therapy is accompanied by damage to the kidneys (1). However, cisplatin is an applicable antineoplastic agent, against solid tumors in clinic (1,2). Cisplatin or cis-diamminedichlorop...
متن کاملThe Nephrotoxicity of Cisplatin
Cisplatin is a cancer chemotherapeutic agent whose cl inical use is complicated by i ts dose related kidney toxicity. Since the histopathological profi le of cisplatin nephrotoxicity appears similar to that of other heavy metals, i t has been commonly presumed that cisplatin nephrotoxicity is related to the platinum moiety. However, the delayed time course and development of cisplatin nephrotox...
متن کاملCisplatin nephrotoxicity: a review.
BACKGROUND Cisplatin is a major antineoplastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. METHODS We reviewed clinical and experimental literature on cisplatin nephrotoxicity to identify new information on the mechanism of injury and potential approaches to prevention and/or treatment. RESULTS Unbound cisplatin is freely filtered at the glomerulus and ...
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ژورنال
عنوان ژورنال: Global Journal of Cancer Therapy
سال: 2015
ISSN: 2581-5407
DOI: 10.17352/gjct.000001